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KMID : 0545120180280010175
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Journal of Microbiology and Biotechnology
2018 Volume.28 No. 1 p.175 ~ p.179
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Lactobacillus plantarum C29 Alleviates TNBS-Induced Memory Impairment in Mice
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Lee Hae-Ji
Jeong Jin-Ju
Han Myung-Joo
Kim Dong-Hyun
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Abstract
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In a preliminary study, Lactobacillus plantarum C29 was found to suppress 2,4,6- trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Therefore, to understand whether an anti-colitic probiotic C29 could attenuate memory impairment, we examined the effects of C29 on TNBS-induced memory impairment in mice. Orally administered Lactobacillus plantarum C29 attenuated TNBS-induced memory impairment in mice in the Y-maze, noble object, and passive avoidance task tests. C29 treatment increased TNBS-suppressed hippocampal brain-derived neurotrophic factor expression and inhibited TNBS-induced hippocampal NF-κB activation and blood LPS levels. Moreover, C29 restored the TNBSdisturbed gut microbiota composition. These findings suggest that C29 can alleviate memory impairment presumably by restoring the gut microbiota composition.
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KEYWORD
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Lactobacillus plantarum, memory impairment, colitis, gut microbiota
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